Attention Deficit/Hyperactivity Disorder
Conditions
Interventions
ADHD Remission Group:None
ADHD Persistent Group:None
Normal Control Group:None
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ADHD Persistent Group: (1)Subjects were children with ADHD who visited the Child Outpatient Clinic of Peking University Sixth Hospital/Institute of Mental Health between 2015 and 2023, will reach 18 years of age by September 2025, and met the following criteria at enrollment (all were assessed using standardized DSM-5 diagnostic interview tools and had complete baseline data): 1) Met DSM-5 diagnostic criteria for ADHD at baseline;2). Baseline age between 6-17 years old, and reached 18 years of age at follow-up;3). IQ >=70;4). Right-handed;5). No history of severe traumatic brain injury resulting in coma;6). No neurological disorders or other severe physical illnesses;7).Absence of metal objects within the body such as cardiac pacemakers, insulin pumps, artificial heart valves, etc;8). No other contraindications for MRI scanning;9).Both the guardian and the subject themselves agreed to participate in the study and signed the informed consent form;10).Subjects were contacted after turning 18 years old and agreed to participate in the follow-up interview;11). Met ADHD diagnostic criteria according to the SCID-5 and CAADID diagnostic interviews at the follow-up assessment; 2.(2) ADHD Remittent Group: Subjects were identical to those in the ADHD Persistent Group and also met the following criteria: 1). Met DSM-5 diagnostic criteria for ADHD at baseline;2).Baseline age between 6-17 years old, and reached 18 years of age at follow-up;3). IQ >= 70;4). Right-handed;5). No history of severe traumatic brain injury resulting in coma;6). No neurological disorders or other severe physical illnesses;7). Absence of metal objects within the body such as cardiac pacemakers, insulin pumps, artificial heart valves, etc;8). No other contraindications for MRI scanning;9). Both the guardian and the subject themselves agreed to participate in the study and signed the informed consent form;10).Subjects were contacted after turning 18 years old and agreed to participate in the follow-up interview;11).Did not meet ADHD diagnostic criteria according to the SCID-5 and CAADID diagnostic interviews at the follow-up assessment. 3.(3) Normal Control Group :1). No current or lifetime diagnosis of ADHD or other psychiatric disorders as confirmed by SCID-5 and CAADID diagnostic interviews; 2). <=3 positive items (scores of 3 or 4 per item) on both inattention and/or hyperactivity-impulsivity subscales of the ADHD Rating Scale (ADHD-RS) and Adult ADHD Self-Report Scale (ASRS); 3). Aged 18–25 years; 4). Right-handed; 5).No current use of psychiatric medications, systematic psychotherapy, or other non-pharmacological interventions within the past three months.
Exclusion criteria
Exclusion criteria: 1.(1) ADHD Persistent and Remission Groups: 1).Subjects who are unwilling to participate in interviews after the age of 18 will be excluded; 2). Those currently in pregnancy or lactation period will also be excluded; 2.(2)Normal Control Group: 1).ubjects who develop major neurological diseases, mental retardation, or other severe physical illnesses during the follow-up period will be excluded; 2). Those who are unsuitable for MRI examination during the follow-up period will be excluded; 3). Subjects who are unwilling to participate in interviews during the follow-up period will be excluded; 4). Those currently in pregnancy or lactation period will also be excluded;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| early adulthood psychiatric diagnosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Outcomes;Factors Influencing Functional Outcomes in Early Adulthood;Brain Development Trajectory; | — |
Countries
China
Contacts
Public ContactCao Qingjiu
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed