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Effect of vitamin C on Postoperative Quality of Recovery in Patients Undergoing Laparoscopic cholecystectomy: A Prospective, Double-Blind, Randomized, placebo-controlled trial

Effect of vitamin C on Postoperative Quality of Recovery in Patients Undergoing Laparoscopic cholecystectomy: A Prospective, Double-Blind, Randomized, placebo-controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108625
Enrollment
Unknown
Registered
2025-09-02
Start date
2025-10-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic cholecystectomy

Interventions

Vitamin C group:vitamin C

Sponsors

Wuxi people’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years old, gender is not limited; 2. ASA level I~III; 3. Patients who intend to undergo LC under general anesthesia.

Exclusion criteria

Exclusion criteria: 1.Patients who have been treated with vitamin C for a long time; 2.Allergy to vitamin C; 3.Patients with other serious diseases, such as heart disease, severe liver and kidney diseases, malignant tumors, etc. 4.Patients with mental disorders or severe neurosis; 5.Uncontrolled high blood pressure; 6.Medications with nonsteroidal anti-inflammatory drugs(NSAIDs),antiplatelet agents or heparins were withdrawn before kidney biopsy ,eliminating interferences in hemostasis; 7.Pregnant or breastfeeding; 8.People with diseases that are advised to be cautious when using vitamin C and vitamin E: cystinuria, gout, hyperoxaluria, oxalate deposition disease, urate kidney stones, diabetes, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sickle cell anemia, iron deficiency anemia; 9.Unable to communicate verbally; 10.Those who refuse informed consent.

Design outcomes

Primary

MeasureTime frame
Quality of recovery scores (QoR-15);

Secondary

MeasureTime frame
Adverse reactions;The number of postoperative hospital stay days (the number of days from the day of surgery to the day of discharge);visual analogue scales;Extubation Time;

Countries

China

Contacts

Public ContactZhang Xin

Wuxi people’s Hospital

xinzhang3@njmu.edu.cn+86 510 8535 1555

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026