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The effect of letrozole supplementation during ovarian stimulation on IVF/ICSI outcomes in patients with varying ovarian responses

The effect of letrozole supplementation during ovarian stimulation on IVF/ICSI outcomes in patients with varying ovarian responses

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108624
Enrollment
Unknown
Registered
2025-09-02
Start date
2024-12-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Letrozole Group:None
Control Group:None

Sponsors

SUN YAT-SEN MEMORIAL HOSPITAL
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
22 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Age between 20-40 years; 2.Undergoing IVF/ICSI assisted reproduction; 3.Patients with or without letrozole (LE) supplementation during controlled ovarian hyperstimulation (COH) (LE added from day 1-5 of COH or from day 1 of COH to the trigger day);

Exclusion criteria

Exclusion criteria: 1.Patients with ovarian tumors; 2.Moderate to severe intrauterine adhesions; 3.Patients with uterine fibroids affecting uterine cavity morphology; 4.Adenomyosis (including adenomyomas); 5.Patients with endometrial precancerous lesions or tumors; 6.Repeated implantation failure; 7.Recurrent miscarriage; 8.Preimplantation genetic testing (PGT) cycles;

Design outcomes

Primary

MeasureTime frame
Mature oocyte (MII) rate;Incidence of severe OHSS;Implantation rate;Clinical pregnancy rate;Number of oocytes retrieved;2PN fertilization rate;High-quality embryo rate;—

Countries

China

Contacts

Public ContactLin Haiyan

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

linhy6@mail.sysu.edu.cn+86 20 8133 2233

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026