Exploration and application of left bundle branch pacemaker combined with If channel blocker in patients with chronic heart failure and atrial fibrillation

Mechanism exploration and application of left bundle branch pacemaker combined with If channel blocker in chronic heart failure complicated with atrial fibrillation

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500108618

Enrollment

Unknown

Registered

2025-09-02

Start date

2023-02-07

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

treatment group: ivabradine

control group:none

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age>=18 years old; 2. LBBP treatment for symptomatic heart failure and persistent or permanent atrial fibrillation, refusal of atrioventricular node ablation; 3. After applying ß blockers and digoxin, the ventricular rate is still poorly controlled; 4. New York Cardiac Function (NYHA) grade II-IV; 5. Patient has at least 1 heart failure-related hospitalization in the past 12 months despite receiving optimal heart failure medication; 6. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.12 lead ECG suggests indoor block; 2. Congenital heart disease requiring cardiac surgery; 3. Chronic kidney disease on dialysis; 4. Severe chronic obstructive pulmonary disease; 5. Those who have contraindications to pacemakers such as infection.

Design outcomes

Primary

Measure	Time frame
ventricular pacing ratio;Echocardiometric indicators;	—

Secondary

Measure	Time frame
Classification of cardiac function;Left atrial anteroposterior diameter, mitral regurgitation, tricuspid regurgitation;	—

Countries

China

Contacts

Public ContactChen Xuezhi

Peking University International Hospital

chenxuezhi@pkuih.edu.cn+86 150 1099 5097

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026