femoral fracture
Conditions
Interventions
Control group:Postoperative use of PCIA formula: 150ug of succinylsufentanil injection + 5mg of tropisetron + 150ml of 0.9% NS. Administration plan: loading dose 2ml, PCA dose 2ml/time, lockout time 1
Experimental Group 1:Postoperative use of PCIA formula: Asperigillin Maleate Injection 30mg + Tropisetron 5mg + 0.9% NS 150ml
Administration plan: Loading dose 1.5mg, PCA can be used 10 minutes after the loading dose, PCA dose 1.75ml/time, lockout time 6 minutes, continuous infusion rate: 3ml/h, 24-hour dosage not exceeding
Experimental Group 2:Postoperative use of PCIA formula: Aspirinol Maleate Injection 30mg + Tropisetron 5mg + 0.9% NS 150ml
Administration plan: Loading dose 1.5mg, PCA can be used 10 minutes after the loading dose, PCA dose 1.75ml/time, lockout time 6 minutes, continuous infusion rate: 4ml/h, total 24-hour dosage not exce
Sponsors
Mianyang 404 Hospital (The First People's Hospital Of Mianyang)
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age (60 to 80 years old); 2. Gender unrestricted; 3. Body Mass Index (BMI) (18 to 32 kg/m2); 4. American Society of Anesthesiologists (ASA) classification I-III; 5. Elective unilateral hip replacement surgery; 6. General anesthesia with endotracheal intubation; 7. Before the trial, informed consent must be obtained from the subject's guardian, and a written informed consent form must be voluntarily signed.
Exclusion criteria
Exclusion criteria: Patients with severe respiratory depression, drug abuse, acute or severe bronchial asthma, drug allergy, severe cardiopulmonary dysfunction, severe liver or kidney dysfunction, a history of mental illness, and those using any illegal or prescribed drugs who are scheduled to undergo hip replacement surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The satisfaction rate of pain relief as indicated by the NRS score within 48 hours after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The occurrence of respiratory depression within 48 hours after the operation.;The occurrence of nausea and vomiting within 48 hours after the operation.;The occurrence rates of urinary retention, constipation and generalized itching within 48 hours after the operation.;The remedial analgesic methods and specific medication usage within 48 hours after the surgery.; | — |
Countries
China
Contacts
Public ContactPang Xiaoyi
Mianyang 404 Hospital (The First People's Hospital Of Mianyang)
Outcome results
None listed