Postoperative Depression in Patients Undergoing Gynecological Tumor Surgery
Conditions
Interventions
Control Group (Group A) :Group A: Following anesthesia induction, an infusion of an equivalent volume of normal saline was initiated at the start of surgery. Postoperatively, patients received a sufen
Esketamine Group 1 (Group B):Group B: Following anesthesia induction, an infusion of esketamine 0.2 mg/kg was initiated at the start of surgery. Postoperatively, patients received a sufentanil-esketam
Esketamine Group 2 (Group C):Group C:Following anesthesia induction, an infusion of esketamine 0.5 mg/kg was initiated at the start of surgery. Postoperatively, patients received a sufentanil-esketami
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years, ASA physical status classification I-III ; 2. Scheduled to undergo gynecological tumor surgery ; 3.Ethically approved, voluntarily signed informed consent, and able to complete scale assessments.
Exclusion criteria
Exclusion criteria: 1.Any contraindications to ketamine or esketamine, such as refractory hypertension, severe cardiovascular disease, or hyperthyroidism. 2.Patients with severe systemic diseases, including significant cardiac, hepatic, or renal dysfunction. 3.Patients with preexisting neuropsychiatric disorders (e.g., mania, schizophrenia) or cognitive impairment. 4. Confirmed or suspected history of substance abuse or chronic use of narcotic sedatives/analgesics. 5. Relative contraindications to general anesthesia, such as known difficult airway or susceptibility to malignant hyperthermia. 6. Concurrent participation in another clinical trial. 7. Patients planned for postoperative ICU admission. 8. Patients deemed ineligible by the attending surgeon, anesthesiologist, or clinical investigator (or their designee).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive Rate of Depressive Symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale Score for Pain;sleep quality ;Hamilton Anxiety Rating Scale (HAMA);Quality of Recovery ; | — |
Countries
China
Contacts
Public ContactXiangdong Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed