Late-life depression
Conditions
Interventions
iTBS Test Group:iTBS stimulation combined with antidepressant
iTBS sham stimulation group:iTBS sham stimulation combined with antidepressant
Antidepressant alone group:Antidepressant
LLD patients without EFD:No intervention, only used as a control
Sponsors
Beijing Anding Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: LLD patients with executive impairment (EFD): 1. Age >= 60 years old, Han nationality, right-handed, regardless of gender; 2. Meet the diagnostic criteria for depressive disorder in DSM-5; 3. Not receiving antidepressant medication during the current episode or taking antidepressant medication for less than 7 days in the last 14 days; 4. HAMD-17 >= 17 points (moderate depression or above); 5. At least one score in the connection test (TMT-A and TMT-B) is one standard deviation or more lower than that of normal controls (compared with the executive function test scores of normal control elderly people recruited by the research group in the early stage); 6. Mini Mental State Examination (MMSE)> 20 points (primary school), MMSE> 24 points (junior high school and above); 7. Primary school education or above, able to understand scale or test content; 8. Obtain written informed consent from the person or his family. Patients with LLD without executive impairment (EFD): 1. Age >= 60 years old, Han nationality, right-handed, regardless of gender; 2. Meet the diagnostic criteria for depressive disorder in DSM-5; 3. Not receiving antidepressant medication during the current episode or taking antidepressant medication for less than 7 days in the last 14 days; 4. HAMD-17 >= 17 points (moderate depression or above); 5. The score in any item in the connection test (TMT-A and TMT-B) shall not be one standard deviation or more lower than that of normal controls (compared with the executive function test scores of normal control elderly people recruited by the research group in the early stage); 6. Mini Mental State Examination (MMSE)> 20 points (primary school), MMSE> 24 points (junior high school and above); 7. Primary school education or above, able to understand scale or test content; 8. Obtain written informed consent from the person or his family.
Exclusion criteria
Exclusion criteria: 1.Persons with abnormal audio-visual perception; 2. A previous history of head disease, brain injury, seizures and other nervous system diseases; 3. Previous history of drug abuse, active suicide attempts, and neuromodulation treatment; 4. Previous serious or unstable cardiovascular, respiratory, immune or other system diseases; 5. Previously or currently diagnosed with the following psychiatric disorders through DSM-5: organic mental disorders, Alzheimer's disease, secondary dementia caused by other causes, schizophrenia, schizoaffective disorders, bipolar disorder, delusional disorders, unspecified mental disorders, alcohol (or drug) dependence or abusers, personality disorders; 6.Contraindications for MRI or transcranial magnetic therapy: such as electronic or metal implants (dentures, arterial clips, pacemakers or metal fixtures, etc.), claustrophobia, etc.; 7. Participated in an interventional clinical trial 3 months before screening; 8. Pregnant, nursing women or those planning to become pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms;Executive function;Brain connectivity level;Cortical oscillation; | — |
Countries
China
Contacts
Public ContactChaomeng Liu
Beijing Anding Hospital Affiliated to Capital Medical University
Outcome results
None listed