Chronic liver disease
Conditions
Interventions
Fatty liver disease observation group:None
Healthy control group:None
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for subjects with fatty liver disease: Attended the fatty liver disease clinic of Shanghai Hospital of Traditional Chinese Medicine and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, according to the 2023 international clinical diagnostic criteria [A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology.2023; 78(6):1966-1986], diagnosed with CLD (SLD) by imaging or prior pathology , agreeing to undergo blood tests and MRI examinations. If willing to undergo liver biopsy, MRI scan and blood tests are performed within 3 days prior to biopsy. Inclusion criteria for healthy volunteers: meet the basic inclusion criteria, no history and clinical symptoms of chronic liver disease (fatty liver, hepatitis, cirrhosis); Normal liver function; Abdominal MRI-PDFF showed liver fat content <5%; No history of long-term alcohol consumption; No use of drugs affecting liver metabolism in the past 6 months; Voluntarily sign the informed consent form
Exclusion criteria
Exclusion criteria: Those who cannot cooperate with or tolerate the examination; Subjects with contraindications to MRI examination and factors affecting image quality; Subjects with mental illness, oncological disease, or severe cardiovascular disease; Pregnant women; No blood test results; Large space-occupying lesions in the liver (long axis diameter > 20mm); Malignancy; renal insufficiency, glomerular filtration rate less than 60 ml/min×1.73m^2; cardiac insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T1 value;R2* value;Proton density fat fraction;Arterial blood flow;Portal vein blood flow;Total blood flow;Arterial fraction;The volume of distribution of the Gd contrast agent through the hepatic compartment;The average time from arterial or portal vein intake through the liver to venous output to venous output;Classification of hepatic steatosis;Iron deposition;Ishak score;METAVIR score;Hemoglobin;Platelet count;Routine coagulation;Total protein;Prealbumin;Alanine aminotransferase;Aspartate aminotransferase;Alkaline phosphatase;?-Glutamyl Transpeptidase;Hyaluronidase;Laminin;Human type III procollagen;Type IV procollagen peptide;Total cholesterol;Triglycerides;High-density lipoprotein;LDL;QSM value; | — |
Countries
China
Contacts
Public ContactYang Shuohui;Lu Fang
Shanghai Municipal Hospital of Traditional Chinese Medicine;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed