Sjögren’s syndrome
Conditions
Interventions
Mucocele group:Labial mucocele
Sj?gren's syndrome:Sj?gren's syndrome
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Mucocele patients: (1) Individuals undergoing surgery for labial mucoceles; (2) aged 18 years or older; (3) willing to donate resected tissue for research and having signed informed consent; (4) with complete clinical records and tissue samples preserved under appropriate conditions during surgery. 2.Sjögren’s syndrome (SS) patients: Patients will be enrolled according to the 2016 ACR/EULAR classification criteria for SS. Eligible participants must meet at least one of the two objective criteria with a score of 3 points: focal lymphocytic sialadenitis in the labial gland with a focus score >= 1 focus/4 mm^2, or positive serum anti-SSA antibodies.
Exclusion criteria
Exclusion criteria: 1.Mucocele patients: (1) Those with a documented history of malignant or inflammatory salivary gland diseases, or salivary gland–related autoimmune disorders (e.g., chronic sialadenitis, mucoepidermoid carcinoma, Sjögren’s syndrome); (2) those who have received radiotherapy or chemotherapy to the head and neck region; (3) those with severe systemic diseases, immune system disorders, or infectious diseases (e.g., hepatitis B, syphilis, HIV); (4) those who have not signed the informed consent form or who withdraw consent during the study. 2.Sjögren’s syndrome (SS) patients: (1) According to the 2016 ACR/EULAR classification criteria for SS: patients with the following conditions, which may present overlapping clinical features or interfere with diagnostic test results, should be excluded — history of head and neck radiotherapy; active hepatitis C virus infection; HIV/AIDS; sarcoidosis; amyloidosis; graft-versus-host disease; and IgG4-related disease. (2) Patients with incomplete diagnostic workup, making it impossible to establish a definitive diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| None; | — |
Countries
China
Contacts
Public ContactXu Zhang
Peking University Hospital of Stomatology
Outcome results
None listed