Stroke
Conditions
Interventions
M1 single-target iTBS stimulation walking group:M1 intermittent transcranial magnetic stimulation
Double - target stimulation walking group:Cerebellar and M1 dual-target iTBS
Sponsors
Zhejiang Rehabilitation Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for stroke (symptoms and signs, imaging indicators, etc.); The diagnosis of cerebral hemorrhage is based on the Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage 2019, and the diagnosis of ischemic stroke is based on the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018. 2. Age 18~75 years old, first onset, disease duration 2-12 months, stable and no progress; 3. Unilateral limb hemiplegia, lower limb Brunnstrom motor function grade III.-V.; 4. Concise mental state screening scale illiteracy >=17 points, primary school >=20 points, middle school >=24 points; 5. Standing balance level 2 or above; 6. Be able to walk independently for more than 30 meters; 7. Patients can tolerate transcranial magnetic stimulation; 8. Patients or legal guardians agree and sign the informed consent form. Note: Those who meet all the above 8 items will be enrolled.
Exclusion criteria
Exclusion criteria: 1. Those who are accompanied by severe cognitive impairment and speech impairment and cannot cooperate with the training; 2. Hemianopia and visual impairment; 3. Vestibular dysfunction such as vertigo and tinnitus; 4. Those who are unable to train with lower limb fractures, severe bone and joint diseases, and severe cardiovascular and lung liver and kidney diseases; 5. Those with orthostatic hypotension; 6. Those with a history of epilepsy, metal pacemakers in the body, metal implants in the brain, and skull defects that are not suitable for transcranial magnetic stimulation therapy or evaluation; 7. Those who are expected to not be able to complete the trial and may not have good compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative electroencephalogram;Near-infrared spectroscopy imaging technology;Surface Electromyography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Three - dimensional gait; | — |
Countries
China
Contacts
Public ContactLinjie Fang
Zhejiang Rehabilitation Medical Center
Outcome results
None listed