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The Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Reward Processing in Substance Use Disorder and Its Neural Mechanisms

The Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Reward Processing in Substance Use Disorder and Its Neural Mechanisms

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108571
Enrollment
Unknown
Registered
2025-09-01
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Substance use disorder

Interventions

Active taVNS:Once daily, 1 hour per session, for 4 consecutive weeks, transcutaneous vagus nerve stimulation applied to the left auricular cavity.
Sham taVNS:Once daily, 1 hour per session, for 4 consecutive weeks, transcutaneous vagus nerve stimulation applied to the left earlobe.

Sponsors

Institute of Psychology, Chinese Academy of Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1.Individuals with substance use disorder who are dependent on crude heroin or heroin. 2.Aged between 18 and 50 years. 3.Education level of junior high school or above. 4.Voluntarily participate in the study and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1.Individuals with a history of using other addictive psychoactive substances (e.g., methamphetamine, Magu, etc.). 2.Individuals with facial or ear pain, or recent ear injuries. 3.Individuals with metal implants in the body (including cardiac pacemakers). 4.Individuals with a personal or family history of epilepsy. 5.Individuals with severe cardiovascular disease or other major medical conditions that may affect the safety of the experiment.

Design outcomes

Primary

MeasureTime frame
Interoception;

Secondary

MeasureTime frame
Craving;FRN;

Countries

China

Contacts

Public Contactliyonghui

Institute of Psychology, Chinese Academy of Sciences

liyonghui@psych.ac.cn+86 186 1263 5067

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026