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Exploring the Impact of Pyroptosis on Renal and Vascular Functions in Preeclampsia

Role of the IP3R-Ca2+ Pathway in Renal Injury and Endothelial Dysfunction in Preeclampsia: A Pyroptosis Perspective

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108565
Enrollment
Unknown
Registered
2025-09-01
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia with proteinuria

Interventions

Control:None
sPE:None
PE:None

Sponsors

Tianjin Central Hospital of Gynecology Obstetrics
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: All parturients were singleton pregnancies. Preeclampsia with proteinuria is defined as the onset of hypertension (BP >= 140/90 mmHg) and proteinuria (24-hour urine protein >= 300 mg) after 20 weeks of gestation, in the absence of prior hypertension. Severe preeclampsia is diagnosed with higher blood pressure readings (systolic BP >= 160 mmHg and/or diastolic BP >= 110 mmHg), more severe proteinuria (24-hour urine protein >= 2 g), signs of preeclamptic convulsions or eclampsia, HELLP syndrome, or acute pulmonary edema.

Exclusion criteria

Exclusion criteria: Exclusion criteria encompass a history of preeclampsia, premature rupture of membranes, illicit drug use, and chronic conditions such as diabetes, chronic hypertension, infections, and renal diseases.

Design outcomes

Primary

MeasureTime frame
pyroptosis;

Secondary

MeasureTime frame
Blood pressure;Serum creatinine;Gestational age;soluble Fms - like tyrosine kinase - 1;fetal Apage score;Kidney injury molecule - 1;perinatal adverse events;Blood urea nitrogen;Placental growth factor;fetal weight;proteinuria;Neutrophil gelatinase - associated lipocalin;

Countries

China

Contacts

Public ContactYanfang Zhang

Tianjin Central Hospital of Gynecology Obstetrics

zhangpuff@163.com+86 22 58287225

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026