patients under general anesthesia
Conditions
Interventions
Gold Standard:Volume expansion test: administer 6ml/kg (IBW) of hydroxyethyl starch 130/0.4 sodium chloride injection to the patient Within 20 minutes,. After Volume expansion, divide the patient into
Index test:Tidal Volume challenge(TVC) : adjust Vt from 6ml/kg to 8ml/kg and consisted1min .Ultrasound was used to measure ?Vpeak-CA before and after TVC
Sponsors
Northen Jiangsu People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: This study selected lung protective ventilation patients (FiO2 40%+VT 6 ml/kg IBW+individualized optimal PEEP)who underwent open abdominal surgery under general anesthesia at Subei People's Hospital from August 2025 to June 2026, regardless of gender, age >18 years old, BMI 18-30 kg/m ^ 2, ASA grade I-III
Exclusion criteria
Exclusion criteria: Mechanical ventilation with Vt>6ml/kg, PEEP>10cmH2O, combined with severe arrhythmia, congenital heart disease, valve disease, or unexplained cardiac dysfunction, bilateral carotid plaques or severe stenosis, severe cerebrovascular disease, severe respiratory system disease, hemodynamic instability, and restricted thoracic movement. Use of vasoactive drugs during the measurement process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| respiratory variation in carotid artery blood flow peak velocity;cardiac index (CI);sensitivity;specifity;Area Under the Curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| stroke Volume variation(SVV);stroke Volume(SV);cardiac output (CO); | — |
Countries
China
Contacts
Public ContactWang Xiaoying
Northen Jiangsu People’s Hospital
Outcome results
None listed