Methamphetamine Dependence
Conditions
Interventions
Treatment Group:Intermittent theta-burst stimulation (iTBS) was administered over the cerebellum, twice daily for 10 consecutive days. The iTBS parameters were as follows: an intraburst frequency of 5
Control Group:Intermittent theta-burst stimulation (iTBS) was administered over the cerebellum using a sham coil, twice daily for 10 consecutive days.
Sponsors
The First Affiliated Hospital with Nanjing Medical University / Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Aged 30 to 50 years (inclusive) ; 2.Meeting the diagnostic criteria for substance-induced dependence in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV); 3.History of methamphetamine dependence for more than 3 years; 4.Abstinent from drugs for at least 1 month; 5.Right-handed; 6.Education level of junior high school or above; 7.No history of drug treatment within the past 6 months; 8.No neurological or psychiatric disorders or related medical history; 9.Informed consent signed by both the participant and their legal guardian.
Exclusion criteria
Exclusion criteria: 1.History of epilepsy, family history of idiopathic epilepsy in first-degree relatives, or use of epileptogenic medications; 2.Impaired or failed function of major organs such as the heart, lungs, liver, or kidneys; 3.Severe cognitive or communication impairments that prevent cooperation; 4.Presence of a pacemaker, metallic implants in the body, or cranial defects; 5.Direct injury to the cerebellum; 6.Use of psychoactive medications—including cholinesterase inhibitors or NMDA antagonists—for treatment within at least 2 weeks prior to cognitive assessment; 7.Inability to cooperate with EEG examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective craving score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting-state brain connectivity measured by electroencephalography;Montreal cognitive;Task-related brain connectivity measured by electroencephalography;Working memory ; | — |
Countries
China
Contacts
Public ContactShen Ying
The First Affiliated Hospital with Nanjing Medical University / Jiangsu Provincial People's Hospital
Outcome results
None listed