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Development and validation of a prognostic prediction model for surgical type A aortic dissection patients based on hematological biomarkers

Development and validation of a prognostic prediction model for surgical type A aortic dissection patients based on hematological biomarkers

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108534
Enrollment
Unknown
Registered
2025-09-01
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Dissection

Interventions

Low-risk group (LRG):None
High-risk group (HRG):None

Sponsors

Fujian Medical University Union Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Consecutive patients with Stanford type A aortic dissection (TAAD) who underwent surgical treatment in the cardiovascular surgery departments of three comprehensive hospitals in China between January 2016 and December 2021 were retrospectively enrolled. The diagnosis of TAAD was confirmed by computed tomography angiography (CTA) in all cases.

Exclusion criteria

Exclusion criteria: 1. History of previous thoracotomy; 2. Active infection at the time of presentation; 3. Comorbidities that may affect preoperative hematologic parameters, including: Active malignancy; Long-term use of medications influencing blood cell counts or coagulation; Autoimmune diseases; Hematologic disorders; Chronic liver disease.

Design outcomes

Primary

MeasureTime frame
All-cause mortality during postoperative hospitalization;All-cause mortality during follow-up;

Secondary

MeasureTime frame
Duration of mechanical ventilation;ICU length of stay;Total hospital length of stay;48-hour thoracic drainage volume;Use of continuous renal replacement therapy (CRRT);Use of extracorporeal membrane oxygenation (ECMO);Incidence of acute kidney injury (AKI);Incidence of low cardiac output syndrome (LCOS);Incidence of permanent neurological dysfunction (PND);Incidence of gastrointestinal bleeding (GB);Incidence of sepsis;Rate of secondary intubation;Rate of tracheotomy;Rate of secondary thoracotomy;

Countries

China

Contacts

Public ContactLinfeng Xie

Fujian Medical University Union Hospital

lysxxlf@vip.qq.com+86 152 8019 1181

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026