Major depressive disorder with suicidal ideation
Conditions
Interventions
major depressive disorder without suicidal ideation:none
major depressive disorder with suicidal ideation:Intravenous injection of ketamine
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for a depressive episode in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), either first episode or recurrence, without psychotic symptoms. 2. Aged 18 to 65; gender unrestricted; Han ethnicity; right-handed. 3. With or without suicidal ideation: A score of >=6 on the Beck Scale for Suicide Ideation (BSS) was used as the criterion for the presence of suicidal ideation. 4. No contraindications to MRI scans such as electronic and metal device implants; 5. Sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Current or past diagnoses that meet the criteria of other significant conditions in DSM-5, excluding depressive disorders, include schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, neurodevelopmental disorders, neurocognitive disorders, disruptive impulse control and conduct disorders; 2. There are serious organic diseases or medical histories of important systems or organs; 3. Having evidence of drug dependence and use of psychoactive substances; 4. Pregnant or lactating female patients; 5. The researchers determined that those with poor compliance or who were not suitable for participation; 6. Those with metal implants or dentures in their bodies, pregnant or lactating women, and those with claustrophobia, etc., cannot undergo MRI scans;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging differences between the group with reduced suicidal ideation and the group with unaltered suicidal ideation;Imaging differences in the group with reduced suicidal ideation before and after ketamine treatment;Neuroimaging features that predict the anti-suicidal effect of ketamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between neuroimaging features and the individual factor scores of MADRS, HAMD, etc.; | — |
Countries
China
Contacts
Public ContactAihong Yu
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed