Chronic obstructive pulmonary disease
Conditions
Interventions
Gold Standard:Forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) ratio of less than 70% after inhalation of bronchodilator
Index test:Electrical impedance tomography
Sponsors
Suzhou Dushu Lake Hospital (The Fourth Affiliated Hospital of Soochow University)
Eligibility
Sex/Gender
All
Age
40 Years to 89 Years
Inclusion criteria
Inclusion criteria: Have COPD risk factors: current or former smokers, smoking index >= 10 pack-years, long-term exposure to biofuel fumes, occupational dust, chemical irritants, etc.; Presence of at least one chronic respiratory symptom with one of the following conditions and quantitatively assessed using a standardized questionnaire (Chronic Cough Rating Scale PC-Q, Chronic Bronchitis Questionnaire CBQ): >= 3 months of persistent or intermittent cough days per year. mMRC dyspnea score >= 1 point after exertion.
Exclusion criteria
Exclusion criteria: Age < 40 years Have contraindications to pulmonary function tests. People not suitable for EIT (such as pacemakers, skin allergies or incompleteness, etc.). Respiratory tract infection or acute exacerbation within 4 weeks prior to screening. Heart attack (myocardial infarction, malignant arrhythmia) within the past 3 months. Hospitalized for heart disease within the last 1 month. Had had thoracic, abdominal and eye surgeries in the past 3 months. Previous lobectomy. Newly discovered and treated malignancy. Receiving anti-tuberculosis drugs or active pulmonary tuberculosis. Other lung diseases such as bronchiectasis, cystic fibrosis, interstitial lung disease, pulmonary thromboembolism, etc. History of psychiatric disorders, auditory hallucinations, visual hallucinations, or use of antipsychotic medications. History of cognitive impairment, including dementia or cognitive impairment. History of high paraplegia. Pregnant or lactating women. Recent use of medications that may affect lung function or EIT outcomes (e.g., diuretics, ß blockers, etc.). Unstable condition and not suitable for participation in the investigator, such as acute COPD exacerbation period, acute asthma attack period, etc. Inability to understand the study process or cooperate with the completion of the investigator, such as severe hearing impairment, language impairment, cognitive impairment, etc. Other circumstances that may affect the conduct of the clinical study and the judgment of the research results in the judgment of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative COPD incidence rate in high-risk groups within five years;The degree of lung function decline in the high-risk group of COPD within five years;Accuracy;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactJunhong Jiang
Suzhou Dushu Lake Hospital (The Fourth Affiliated Hospital of Soochow University)
Outcome results
None listed