Colorectal cancer
Conditions
Interventions
Control group:PCIA: Sufentanil 150 µ g+ tropane 5mg+0.9%NS147ml, initial 5 µ g, additional 1ml each time, locked for 10 minutes, continuous 3ml/h
Experimental Group 1:PCIA: Taigilidine 7.5mg+ Tropane 5mg+0.9%NS142.5ml, initial 0.75mg, additional 1ml each time, locked for 10 minutes, continuous 3ml/h
Experimental Group 2:PCIA: Taigilidine 7.5mg+ Tropane 5mg+0.9%NS142.5ml, initial 1mg, additional 1ml each time, locked for 10 minutes, continuous 3ml/h
Sponsors
Mianyang 404 Hospital (The First People's Hospital Of Mianyang)
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 19 to 65 who are scheduled to undergo radical resection of abdominal colorectal cancer under general anesthesia; 2.No gender restrictions; 3.American Society of Anesthesiology (ASA) classification I-III; 4.BMI: 18-32kg/m^2; 5.Patients who can cooperate and correctly understand Chinese and express their intentions; 6.Patients who agreed to the trial protocol and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients who do not agree to conduct experimental research; 2.Patients with ASA grade greater than grade III; 3.Known or suspected gastrointestinal obstruction, including patients with paralytic ileus; 4.Patients with acute or severe bronchial asthma in the absence of vital sign monitoring or life resuscitation equipment; 5.Patients with severe liver dysfunction; 6.Patients with abnormal mental states; 7.Patients who are allergic to any component of opioid drugs or investigational drugs; 8.Patients with severe respiratory depression, such as those with an oxygen saturation level below 90%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The VAS score of the patient at rest 30 minutes after the tracheal tube was removed.; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores at rest and passive turning at 6 hours, 12 hours, 24 hours and 48 hours after the operation;The dosage of remifentanil and sufentanil during the operation;The use of remedial analgesic drugs within 48 hours after the operation;The number of compressions of the PCIA within 48 hours after the operation;The number of times sleep was interrupted due to pain on the night of the surgery;Complications such as nauseas and vomiting; | — |
Countries
China
Contacts
Public ContactWang Jiao
Mianyang 404 Hospital (The First People's Hospital Of Mianyang)
Outcome results
None listed