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Dose–Response Relationship of Esketamine for Suppressing Laryngeal Mask Airway Insertion Response in Shoulder Arthroscopy Patients under Lidocaine Combination

Dose–Response Relationship of Esketamine for Suppressing Laryngeal Mask Airway Insertion Response in Shoulder Arthroscopy Patients under Lidocaine Combination

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108472
Enrollment
Unknown
Registered
2025-09-01
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with shoulder joint injury scheduled for arthroscopic shoulder surgery

Interventions

Group N (saline):Intravenous administration of an equal volume of normal saline
Group L (lidocaine):Intravenous administration of lidocaine 0.5 mg/kg

Sponsors

Ningbo No.6 Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18-65 years old, gender is not limited; 2. Elective shoulder arthroscopic surgery, with laryngeal mask general anesthesia; 3. ASA grade I-II; 4.BMI 18-30kg/m^2; 5. No history of airway abnormalities or difficult intubation; 6. Voluntarily participate and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with cardiac insufficiency, hepatic or renal dysfunction, or severe respiratory diseases; 2.Patients with psychiatric disorders, impaired consciousness, or communication difficulties preventing cooperation with the investigators; 3.Patients with a history of airway hyperreactivity, such as laryngospasm or bronchial asthma; 4.Patients allergic to the study medications, including lidocaine, propofol, or esketamine; 5.Patients with intracranial hypertension, epilepsy, psychiatric history, or contraindications to NMDA receptor antagonists; 6.Patients who have used other sedative or analgesic drugs within the past week.

Design outcomes

Primary

MeasureTime frame
Laryngeal mask airway insertion response;

Secondary

MeasureTime frame
Vital signs at different time points;Adverse reactions from the start of induction to within 3 minutes after intubation;Time required for insertion and attempts;

Countries

China

Contacts

Public ContactZhang Liangguang

Ningbo No.6 Hospital

lgzhang1987@163.com+86 13967825529

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026