Severe pneumonia
Conditions
Interventions
Experimental group (Oxycodone and Dexmedetomidine combination group):Oxycodone hydrochloride injection 30 mg (10 mg/vial) was diluted with 0.9% NaCl solution to a total volume of 50 ml and administere
Control group (Remifentanil and Dexmedetomidine combination group):Remifentanil injection 4 mg (1 mg/vial) was diluted with 0.9% NaCl solution to a total volume of 50 ml and administered by continuous
Sponsors
The 242nd Hospital Affiliated to Shenyang Medical College
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years; 2. Subjects meeting the diagnostic criteria for severe pneumonia as defined by the American IDSA/ATS guidelines, requiring endotracheal intubation and mechanical ventilation; 3. Expected mechanical ventilation duration >= 24 hours, with enrollment within 48 hours of initiation of ventilation; 4. Subjects requiring ICU monitoring; 5. Subjects who agree to participate in the study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of allergy to study medications; 2. Conditions requiring deep sedation; 3. Severe hepatic or renal dysfunction; 4. Uncorrected hypovolemic shock; 5. Severe systemic diseases; 6. Severe psychiatric disorders or cognitive impairment; 7. History of delirium; 8. Prior or recent use of sedatives, analgesics, or other medications affecting sedation assessment; 9. History of substance abuse and/or alcoholism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 72 hours (assessed by CAM-ICU); | — |
Secondary
| Measure | Time frame |
|---|---|
| CPOT scores and RASS scores ;Incidence of agitation;Weaning success rate;Hemodynamic changes; the occurrence of adverse reactions during treatment, including nausea, vomiting, respiratory depression, hypertension, hypotension, bradycardia, tachycardia, and other related events.; | — |
Countries
China
Contacts
Public ContactHongwei Gao
The 242nd Hospital Affiliated to Shenyang Medical College
Outcome results
None listed