Femoral fracture, humeral fracture, Spinal fracture
Conditions
Interventions
Control group:none
Test group:Controlled hypotension with pump infusion of remifentanil
Sponsors
Department of Anesthesiology, Changdu People's Hospital of Xizang
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 18-75 years old, ASA I-III; 2. Plateau (altitude >= 2500 meters) permanent residents (residence time > 6 months); 3. Planned major orthopedic surgery: hip / knee replacement, femur / tibiofibula reduction and internal fixation, spinal fusion (operation duration is expected to be >= 2 hours).
Exclusion criteria
Exclusion criteria: 1. Severe cardiovascular and cerebrovascular disease (EF 133 µ mol/l); 3. Uncontrolled hypertension (preoperative systolic blood pressure > 180 mmHg); 4. Coagulation dysfunction (INR > 1.5, platelet < 100 × 10^9 /l); 5. Severe respiratory disease (preoperative spo2 < 90%).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine output;lactic acid; | — |
Countries
China
Contacts
Public ContactLei Zou
Department of Anesthesiology, Changdu People's Hospital of Xizang
Outcome results
None listed