Acute ischemic stroke
Conditions
Interventions
Intravenous thrombolysis:None
Sponsors
The Second Hospital & Clinical Medical School, Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, 2. Presenting with acute stroke with the clinical symptoms and signs, 3. Acute ischemic stroke was determined according to imaging examination (CT/MRI), 4. Patients who have indications for intravenous thrombolysis within 24 hours of onset according to guidelines, 4. Obtainment of informed consent from the patient or their legal guardian.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage confirmed by cranial computed tomography (CT) or magnetic resonance imaging (MRI), including cerebral parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, subdural/extradural hematoma, etc; 2. History of prior intracranial hemorrhage; 3. Severe head trauma or stroke within the past 3 months; 4. Intracranial tumor, giant intracranial aneurysm; 5. Intracranial or intraspinal surgery within 3 months; 6. Major surgical procedures within the past 2 weeks; 7. Gastrointestinal or genitourinary bleeding within the past 3 weeks; 8. Active visceral bleeding; 9. Aortic arch dissection; 10. Arterial puncture at a non-compressible site within the previous week; 11. Elevated blood pressure: systolic pressure >180 mmHg or diastolic pressure >100 mmHg, and difficult to control with medication; 12. Acute bleeding tendency, including platelet count 1.7 or PT >15 s; 15. Use of thrombin inhibitors or Xa factor inhibitors within 48 hours, or abnormal laboratory tests (such as APTT, INR, platelet count, ECT, TT, or Xa factor activity assay, etc.); 16. Blood glucose level 22.22 mmol/L, and difficult to correct; 17.Head CT or MRI indicates a large area of infarction (infarction area>1/3 of the middle cerebral artery supply area); 18. Pregnancy or postpartum status; 19. In-hospital stroke; 20. Diagnostic workup is uncertain or suggests an event other than stroke as the likely cause.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| door to needletime (DNT);Incidence of Symptomatic Intracranial Hemorrhage within 7 Days and 90-Day Mortality Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of Cases with DNT <=60 Minutes (%);door to needletime, DNT;MRS (Modified Rankin Scale) score at 90 days;Incidence of asymptomatic intracranial hemorrhage (aSICH) within 7 days;Incidence of non-intracranial hemorrhagic complications (including gastrointestinal bleeding, urinary tract bleeding, oral or nasal mucosal bleeding, subcutaneous hematoma, etc.);Incidence of non-hemorrhagic serious adverse events (including cerebral herniation, pneumonia, respiratory failure, circulatory failure, stress ulcer, secondary epilepsy, urinary tract infection, sepsis, renal failure, acute coronary syndrome, venous thrombosis, and psychiatric symptoms, etc.); | — |
Countries
China
Contacts
Public ContactZhang Zhenchang
The Second Hospital & Clinical Medical School, Lanzhou University
Outcome results
None listed