Colorectal cancer
Conditions
Interventions
Index test:BEST1+TKTL1+ monocyte detection in Peripheral blood
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Age >=18 and >= 80 years old; 2: Patients admitted to Beijing Hospital with primary CRC diagnosed with pathology through endoscopic examination or operation; had not received any anti-tumor therapy such as radiotherapy, chemotherapy, targeted therapy or immunotherapy before surgery. Precancerous lesions of colorectal cancer diagnosed with pathology through endoscopic examination or operation. 3: Multiple primary tumors were excluded by endoscopy and imaging; 4: Healthy subjects: no obvious symptoms or signs of discomfort; No diseases of the heart, liver, spleen, lung, kidney and other organs were excluded from comprehensive physical examination in our hospital. No gastric cancer, colorectal cancer, or pre-colorectal cancer lesions were confirmed within 3 months by endoscopy.
Exclusion criteria
Exclusion criteria: 1: History of other malignant diseases in the past 5 years; 2: Patients who had received chemotherapy, radiotherapy, targeted therapy, immunotherapy, interventional therapy, cytokine therapy or biologics before surgery; 3: Patients with secondary primary tumors, including gastrointestinal neuroendocrine tumors, gastrointestinal stromal tumors, and lymphomas; 4: Patients with severe bleeding disorders, severe coagulation dysfunction, or local/systemic infections that are not readily accessible for surgery or biopsy; 5: Severe internal organ complications; 6: Refuse further pathology and imaging tests; 7: Pregnancy, lactation, mental illness; 8: Other severe, acute, or chronic medical conditions or abnormalities in laboratory tests that the investigator determines may increase the risk associated with study participation or may interfere with the interpretation of the study results; 9: Patients identified by the investigator as having poor adherence or other conditions that made them ineligible to participate in the trial. 10: Systemic infection or inflammation, including: lung, gastrointestinal tract, pancreas, biliary system, abdominal cavity, urogenital system, skin and soft tissues, nervous system, endocardium, pericardium, periodontal, hematogenous infection. 11: Among healthy subjects, those with a history of inflammatory bowel disease or precancerous lesions of colorectal cancer should be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BEST1+TKTL1+ monocyte diagnostic model of CRC;Accuracy;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactJing Xu
Fusui Ji
Outcome results
None listed