Adenoidal hypertrophy
Conditions
Interventions
VD3 Supplemental Group:Endogenous therapy Vitamin D3 supplementation
Standard treatment group:Endogenous treatments: hormonal nasal sprays, anti-allergy treatments, and antibiotics
Sponsors
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects are between 1 and 12 years old; 2. All subjects have chronic mouth breathing lasting more than 3 months; 3. Endoscopy and nasopharyngeal lateral X-ray confirm that the airway obstruction rate is more than 60% with or without tonsil hypertrophy; 4. Collect swabs from the surface of adenoids for bacterial culture; 5. By obtaining intact lobular tissue in the central region of the adenoid, including the mucosal area, B-cell germination center, T cell area, and medullary area, it is convenient to observe the comprehensive structural changes of the adenoid.
Exclusion criteria
Exclusion criteria: Patients with acute infection, pneumonia, autoimmune disease, Henoch-Schoenlein purpura, immunodeficiency, craniofacial malformations, previous adenoid/tonsil surgery, or incomplete documentation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical intervention rate (adenoidectomy and/or adenoid & tonsillectomy) within 2 years of treatment initiation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Procedure-specific rates;Age- and sex-stratified analyses; | — |
Countries
China
Contacts
Public ContactYehai Liu; Ye Tao
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed