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Mechanism of EMX1 Improving Neural Projection by Regulating Neuroplasticity After Cerebral Ischemia-Reperfusion

Research on the molecular mechanisms of protecting neural projections after cerebral ischemia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108419
Enrollment
Unknown
Registered
2025-08-29
Start date
2025-07-03
Completion date
Unknown
Last updated
2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral ischemia-reperfusion

Interventions

Peritumoral brain tissue:NA
Rebleeding tissue after cerebral ischemia:NA

Sponsors

The First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 and above who have undergone rebleeding after cerebral ischemia or brain tumor surgery; 2. The specimens were obtained between December 2021 and May 2025; 3. There are complete pathological specimens available for research and analysis; 4. It has a clear clinical diagnosis and complete medical records; 5. The preservation conditions of surgical specimens meet the requirements of molecular biology research.

Exclusion criteria

Exclusion criteria: 1. The quality of surgical specimens is poor or they are improperly preserved, making them unsuitable for molecular biological analysis; 2. The clinical data is incomplete and cannot provide sufficient background information on the disease; 3. The patient clearly expressed his disagreement with the use of his surgical specimens for research purposes; 4. Surgical specimens from pregnant women or minors; 5. Combined with other systemic diseases that may significantly affect the inflammatory state of brain tissue (such as autoimmune diseases); 6. Having received drug treatment that may significantly affect the phenotype of neuronal cells before the surgery;

Design outcomes

Primary

MeasureTime frame
The changes in the fluorescence intensity of Emx1 in brain tissue;

Countries

China

Contacts

Public ContactHaiying Li

The First Affiliated Hospital of Soochow University

lhy1015@suda.edu.cn+86 512 67507192

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026