Viral hepatitis B
Conditions
Interventions
CpG adjuvant low dose group:Experimental vaccine
Positive control group:hepatitis B vaccine
CpG adjuvant high dose group:Experimental vaccine
Sponsors
Shandong Center for Disease Prevention and Control
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Be 18 years of age and above on the day of enrollment and can provide legal identification, voluntarily participate and agree to sign the informed consent; 2.The patient passed the physical examination, and was able to participate in regular visits according to the requirements of the experiment, without vaccination contraindications.
Exclusion criteria
Exclusion criteria: 1.History of viral hepatitis B; 2.Users who have received immunoglobulin, blood or blood-related products within 3 months prior to vaccination or during planned trials; 3.Have used another investigational or unregistered product (drug or vaccine) in the 3 months prior to vaccination, or are participating in or plan to participate in another clinical trial; 4.Receive any vaccines within 14 days prior to vaccination; 5.Acute febrile illness or acute infectious disease within 3 days prior to vaccination, or use of antipyretic, analgesic or anti-allergic drugs 3 days prior to vaccination; 6.Urine pregnancy test positive, pregnant, breastfeeding, or within 1 year of planning to have a child (for women of childbearing age); 7.Any other conditions that the investigator believes may affect the evaluation of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive conversion rate of anti-HBS antibody;Positive rate of anti-HBS antibody; | — |
Countries
China
Contacts
Public ContactLi Zhang
Shandong Center for Disease Prevention and Control
Outcome results
None listed