Postoperative recovery in patients undergoing Laparoscopic Sleeve Gastrectomy
Conditions
Interventions
Tegileridine Fumarate group (T group):Administration of Tegileridine Fumarate for anesthesia induction and postoperative analgesia
Sufentanil group (S group):Administration of Sufentanil for anesthesia induction and postoperative analgesia
Sponsors
The First People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with a BMI >=40 kg/m^2, a BMI of 35-40 kg/m^2 with associated complications, or a BMI of 30-35 kg/m^2with poorly controlled type 2 diabetes and/or hypertension; 2.Aged between 18 and 65 years; 3.ASA physical status classification of I-III; 4.Clear understanding and voluntary participation in this study, with signed informed consent; 5.All patients received training on VAS scoring and the use of patient-controlled analgesia pumps.
Exclusion criteria
Exclusion criteria: 1. Allergy to experimental drugs; 2. Patients with acute or severe bronchial asthma; 3. Known or suspected gastrointestinal obstruction, including patients with paralytic intestinal obstruction; 4. Patients who have been taking non-steroidal anti-inflammatory drugs, opioids, and sedatives for a long time; 5. Any neurological or psychiatric illness, including history or treatment of substance abuse, anxiety, or depression; 6. Patients with vital organ dysfunction, cardiac dysfunction (unstable ischemic heart disease, severe pulmonary hypertension, etc.), liver dysfunction (palnine aminotransferase or aspartate aminotransferase value>=2 times the upper limit of normal or total bilirubin >1.5 times the upper limit of normal), renal dysfunction (serum creatinine >=2mg/dl.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to first rescue analgesia;cumulative opioid consumption in PCIA;CRP;postoperative antiemetic usage rate;IL-6;amount of rescue analgesia required postoperatively;patient satisfaction with analgesia;number of PCIA attempts;Adverse reactions within 72 hours after surgery;Kroenke Score;VAS of pain scores (at rest/ during turning over); | — |
Countries
China
Contacts
Public ContactYong Wu
The First People's Hospital of Lianyungang
Outcome results
None listed