Infertility
Conditions
Interventions
Experimental group: NICS + Morphological Assessment:Patients undergoing blastocyst frozen embryo transfer (FET) cycles will undergo single frozen blastocyst transfer selected based on morphologica
Control group: Morphological Assessment:Patients undergoing blastocyst frozen embryo transfer (FET) cycles will undergo single frozen blastocyst transfer selected based on morphological grading
Sponsors
General Hospital of Eastern Theater Command, People's Liberation Army of China
Eligibility
Sex/Gender
Female
Age
35 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1 Female patients aged 35–42 years or with prior pregnancy loss or a history of embryo implantation failure; 2 IVF/ICSI treatment cycle; 3 Planned single blastocyst transfer; 4 Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1PGT (Preimplantation Genetic Testing) cycles; 2 Female medical history of: (1). Thyroid disorders ;(2). Adrenal diseases; (3). Sexually transmitted infections ;(4). Genetic disorders;(5). Psychiatric or psychological disorders ; 3 Uterine abnormalities, including: Uterine malformations (e.g., unicornuate uterus, didelphic uterus), untreated septate uterus, adenomyosis, submucosal fibroids, endometrial polyps, or intrauterine adhesions (including history of Asherman’s syndrome). Note: Patients with treated conditions may be included; 4 Contraindications to ART or pregnancy, such as: Poorly controlled type I/II diabetes, Undiagnosed or impaired hepatic/renal function (based on blood tests), Deep vein thrombosis (DVT) or pulmonary embolism (PE), History of cerebrovascular accident (CVA),Uncontrolled hypertension, Cardiac disease,Active malignancy,Severe anemia,Unexplained vaginal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate;Miscarriage rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Live birth rate;Cumulative clinical pregnancy rate ;Cumulative onging pregnancy rate ;Cumulative live birth rate ;Cumulative miscarriage rate ; | — |
Countries
China
Contacts
Public ContactLi Chen
General Hospital of Eastern Theater Command, People's Liberation Army of China
Outcome results
None listed