Postoperative Pulmonary Complications (PPCs)
Conditions
Interventions
Pressure-Controlled Ventilation (PCV) group:Pressure-controlled ventilation (PCV) mode was employed during mechanical ventilation.
Volume-Controlled Ventilation (VCV) group:Volume-controlled ventilation (VCV) mode was utilized during mechanical ventilation.
Sponsors
Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1. Voluntary provision of written informed consent 2. Adult patients aged 18-85 years 3. Diagnosis of any of the following conditions: Benign pulmonary tumors; Pulmonary fibrosis; Bronchiectasis; Congenital lung diseases; Severe chronic obstructive pulmonary disease (COPD; GOLD stage 3-4); Traumatic lung injury; Chronic pulmonary embolism 4. Scheduled for elective pulmonary resection under general anesthesia with anticipated one-lung ventilation duration =60 minutes 5. ASA physical status classification I-III
Exclusion criteria
Exclusion criteria: 1. History of acute lung injury (ALI) prior to surgery 2. Acute respiratory distress syndrome (ARDS) or respiratory failure within the past 3 months 3. Severe comorbidities, including: Advanced liver dysfunction (e.g., hepatic failure or Child-Pugh class B/C) 4. Chronic kidney disease with glomerular filtration rate (GFR) II) 6. Poorly controlled asthma or FEV1% <60% predicted 7. Investigator-determined ineligibility based on: Collected baseline data (age, sex, BMI, medical history, medication use); Overall assessment of suitability for study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Adverse Events;Hemodynamic Changes and Postoperative Pain Scores;Oxygenation Index at Different Perioperative Time Points;Graded assessments performed via chest radiography and routine laboratory tests on postoperative day (POD) 2 or 3, and when any pulmonary complications were clinically suspected.;Duration of Mechanical Ventilation Weaning;Incidence of Postoperative Pulmonary Complications (PPCs) During the First Week, Including Comprehensive Outcome Analysis and Individual PPCs Analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac tissue and plasma/urine biomarkers, including sCD40L, NT-proBNP, BNP, creatinine, and lipid profiles;Length of Stay in ICU/Intermediate Care Unit and Time to Discharge;Incidence of Postoperative Extrapulmonary Complications (PEPCs) During the First Week;Incidence of Pulmonary Complications Occurring Between Postoperative Days 7-30;Major In-Hospital Cardio- or Cerebrovascular Events (e.g., mortality, stroke, myocardial infarction, heart failure) and Acute Kidney Injury (AKI); | — |
Countries
China
Contacts
Public ContactLiu Kexuan
Nanfang Hospital, Southern Medical University
Outcome results
None listed