Aortic Diseases
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patient age between 18 and 65 years; (2) Patient or legally authorized representative capable of understanding the trial purpose, voluntarily participating, and providing signed informed consent; (3) Aortic dissection confirmed by CTA (Computed Tomography Angiography) with disease onset <= 14 days.?
Exclusion criteria
Exclusion criteria: (1) Aortic dissection caused by trauma, connective tissue disease (e.g., Marfan syndrome), or infectious factors;? ??(2) Comorbidities beyond hypertension, including diabetes, obesity (BMI >= 30), or immune system disorders;? ??(3) History of aortic/cardiac diseases or related surgeries;? ??(4) Patients with major gastrointestinal surgery (e.g., cholecystectomy, appendectomy, bowel resection) within 5 years;? ??(5) Gastrointestinal disorders: active infection, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), chronic constipation/diarrhea, or digestive tract tumors;? ??(6) Recent use (within 3 months) of antibiotics, glucocorticoids, immunosuppressants, or probiotics;? ??(7) Patients with intestinal hypoperfusion;? ??(8) Females during menstruation or pregnancy;? ??(9) Patients refusing surgical intervention and requesting conservative management.??
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota;Plasma metabolite; | — |
Countries
China
Contacts
Public ContactJia Hu
Department of Cardiovascular Surgery, West China Hospital, Sichuan University
Outcome results
None listed