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In vitro and clinical studies of novel bioactive materials for wide root canal filling

In vitro and clinical studies of novel bioactive materials for wide root canal filling

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108361
Enrollment
Unknown
Registered
2025-08-28
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic apical periodontitis

Interventions

Experimental group:C Root BP:Root canal filling
Experimental group:C Root BP+C Root SP:Root canal filling
Control group: MTA:Root canal filling

Sponsors

Peking University Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 20-60 years, who are informed and consent to the treatment, and willing to cooperate with the treatment, will sign the informed consent form. 2.The patient is in good health, has no systemic diseases, and denies a history of drug allergies. 3.The affected tooth is a single-rooted canal tooth, with the maximum diameter of the periapical radiolucent lesion being less than 10mm. 4.The affected teeth are permanent teeth without cracks, with good periodontal status, probing depth (PD) < 4mm, tooth mobility<= grade ?, and alveolar bone resorption <= 1/2. 5.The patient has a normal mouth opening and is able to cooperate with and tolerate the treatment.

Exclusion criteria

Exclusion criteria: 1.Patients with systemic diseases such as hypertension and heart disease, or those with factors like dental fear, severe gag reflex, excessively small mouth opening, and poor compliance, who are unable to cooperate with the completion of treatment or follow-up visits. 2.The probing depth of the affected tooth is = 4mm, or the tooth mobility is >= grade ?. 3.analgesic or antibiotics are used before treatment.

Design outcomes

Primary

MeasureTime frame
Postoperative pain level;Clinical operability;Root canal filling quality;Treatment success rate;

Countries

China

Contacts

Public ContactZhu Wenhao

Peking University Hospital of Stomatology

zhweha@163.com+86 10 8219 5586

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026