Diabetes cognitive dysfunction
Conditions
Interventions
Diabetes without cognitive impairment group:None
Diabetes with cognitive impairment group:None
Control group:None
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for diabetic patients: (1) Meet the diagnostic criteria for diabetes, and select diabetic patients according to the American Diabetes Association diagnostic criteria for type 2 diabetes: glycated hemoglobin (HbA1c) >=6.5% (48 mmol/mol), fasting blood glucose >=7.0mmol/L (126mg/dL), oral glucose tolerance test (OGTT) 2-hour postprandial blood glucose >=11.1mmol/L (200 mg/dL), random blood >=in patients with typical hyperglycemic symptoms or hyperglycemic criticism 11.1mmol/L (200 mg /dL); (2) Age 40-85 years old; (3) Sufficient visual and auditory discrimination to undergo neuropsychological testing; (4) Patients undergoing downward femoral head replacement surgery under spinal anesthesia 2. Selection criteria for the control group: (1) Age and gender are similar to those in the diabetic group; (2) People with normal glucose tolerance checked by OGTT test; (3) Patients with femoral head replacement surgery without underlying neuraxial anesthesia
Exclusion criteria
Exclusion criteria: 1. Patients with cognitive dysfunction before the diagnosis of diabetes; 2. Those who have experienced diabetic acute complications in the past six months, such as ketoacidosis, hyperosmolar coma, hypoglycemia (blood glucose <2.8 mmol/L), etc; 3. Patients with neurological diseases that can affect cognitive function, including: AD, vascular dementia, Parkinson's disease, inflammatory lesions of the central nervous system, intracranial tumors, epile, etc; 4. Patients with a history of long-term heavy drinking, women during lactation/pregnancy; patients who have been taking sedatives and hypnotics a long time; 5. Patients with organic diseases such as heart, liver, and kidney, and patients with known tumors; 6. Those who have had infections in the month; patients with contraindications to intrathecal anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lncRNA-MEG3 ; | — |
Secondary
| Measure | Time frame |
|---|---|
| General biochemical indicators;Cognitive function; | — |
Countries
China
Contacts
Public ContactWang Zhihua
Hainan General Hospital
Outcome results
None listed