Chronic hepatitis B
Conditions
Interventions
PEG-IFNa-2b group:NA
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily enrolled, able to understand and sign the informed consent form; 2. Age 18-65 years old (including 18 and 65), gender is not limited; 3. History of HBsAg positivity for at least 6 months or other evidence suggestive of chronic hepatitis B; 4. Baseline HBsAg< 1000IU/mL; HBV DNA<500IU/ml; 5. Baseline HBeAg positive; 6. NAs for at least 12 consecutive months; 7. Patient meets indications for interferon therapy and is expected to receive treatment with pegylated interferon a-2b.
Exclusion criteria
Exclusion criteria: 1. Combined with hepatitis A, hepatitis C, hepatitis D, hepatitis E and/or HIV infection; 2. Chronic liver diseases caused by other causes, such as alcoholic hepatitis, drug-induced hepatitis, autoimmune liver disease, moderate to severe steatohepatitis and hepatocellular carcinoma; 3. Those who plan to receive telbivudine treatment during the study period; 4. Planned use of other drugs with anti-HBV efficacy (including Chinese herbal medicine) during the study; 5. Other situations that the investigator considers unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatitis B Five Tests;ALT AST;Blood routine; | — |
Countries
China
Contacts
Public ContactXin Yongning
Qingdao Municipal Hospital
Outcome results
None listed