Lower extremity fractures
Conditions
Interventions
Afentanil group (group A): At 5 min before the end of operation, Group A was injected with 10 ug/kg alfentanil intravenously,
Control Group (Group C):At 5 min before the end of operation, Group C was injected with volume saline intravenously,
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who undergo closed reduction of lower limb fractures under general anesthesia electively 2. ASAI.~III. grade, age 18~70 years old, BMI 18~28kg/m^2
Exclusion criteria
Exclusion criteria: 1. Severe heart, liver and kidney dysfunction before surgery 2. Concomitant sleep apnea syndrome 3. Chronic use of opioids, chronic use of nonsteroidal anti-inflammatory drugs, or use of opioids within 48 hours before surgery 4. Use of other drugs that affect opioids (antiepileptics, antidepressants, antipsychotics, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of agitation during awakening;Resting highest VAS analgesic score;Mean arterial pressure and heart rate before and after administration of intervention drugs and during wake-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of chills;Incidence of choking reactions; | — |
Countries
China
Contacts
Public ContactHao Yujuan
Anqing Municipal Hospital
Outcome results
None listed