connective tissue disease
Conditions
Interventions
Tacrolimus group:Tacrolimus treatment
Non-tacrolimus group:Non-tacrolimus treatment
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1 Females aged 18–45 years old. 2 Meet the diagnostic criteria for CTD (including SLE, myositis, antiphospholipid syndrome, Sjögren's syndrome, etc.). 3 Confirmed pregnancy with gestational age less than 12 weeks at the time of enrolment. 4 SLE patients: SLEDAI score >= 4 points, with no other severe complications or meeting the study criteria as assessed by a physician. 5 Have complete clinical data and have signed an informed consent form. 6 Patients with a pregnancy plan or currently trying to conceive. 7 Good compliance and willingness to participate in follow-up visits.
Exclusion criteria
Exclusion criteria: 1 Severe heart, kidney, liver disease, or other immune system disorders. 2 History of latent tuberculosis infection or tumours. 3 Unwillingness to participate in the study or inability to cooperate with sample collection. 4 Other conditions deemed unsuitable for enrolment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tacrolimus blood concentration;Pregnancy outcomes; | — |
Countries
China
Contacts
Public ContactHaili Shen
The Second Hospital of Lanzhou University
Outcome results
None listed