Conversion therapy after failure of antiretroviral therapy in Hiv-Infected patients
Conditions
Interventions
DTG 3TC TDF treatment group:DTG+3TC+TDF was used as the conversion treatment
BIC/FTC/TAF treatment group:BIC/FTC/TAF was used as the conversion treatment
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old; 2. First-line NNRTIs 2NRTIs regimen treatment >=6 months with two consecutive (>=7 days apart) viral load >=200 copies/mL, or a single viral load greater than 1000 copies/mL. 3. Good compliance (patients with poor adherence, defined as missed doses three or more times within a month, need to be re-evaluated after 4 weeks of enhanced compliance); 4. No INSTIs treatment; 5. Signed informed consent and voluntarily participated in the study.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Severe abnormal liver function (ALT>=3 times the upper limit of normal value); 3. Estimated glomerular filtration rate (eGFR) < 50 mL/min/1.73 m^2 (CKD-EPI formula); 4. Combined with serious opportunistic infections, malignant tumors or mental illnesses, which may affect treatment compliance; 5. Need for anti-tuberculosis therapy; 6. Need for anti-HCV therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Viral suppression rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunological indicators;The percentage of participants with plasma HIV-1 RNA levels <50 copies/mL; | — |
Countries
China
Contacts
Public ContactDai Lili
Beijing Youan Hospital, Capital Medical University
Outcome results
None listed