Pain
Conditions
Interventions
Bupivacaine liposome group:During the skin suturing procedure, 10 ml of a total of 133 mg of bupivacaine liposome was administered via the epidural route.
Bupivacaine hydrochloride group:During the skin suturing procedure, 10 ml of 0.0938% bupivacaine hydrochloride was administered via the epidural route.
Sponsors
Xiamen Hospital Affiliated to Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~75 years old (male and non-pregnant women); 2. ASA grade I~III; 3. Elective surgery; 4. Voluntarily participate and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Body weight less than 40kg, body mass index greater than or equal to 35kg/m^2; 2. Patients who are known to be allergic to local anesthetics used in this study; 3. History of allergy to opioids or severe allergy to other drugs; 4. History of opioid abuse and long-term use of psychotropic drugs; 5. Preoperative patients with severe heart disease (NYHA cardiac function classification >3), severe renal insufficiency (serum creatinine >1.8mg/dL (159.1µmol/L) or receiving renal function replacement therapy), severe hepatic insufficiency (modified Child-Pugh grade C); 6. History of clinically significant disease (determined by investigation results); 7. Blood donation or massive blood loss within 6 weeks before screening, family history of thrombosis, or participation in drug research within 30 days 8. Epidural puncture is contraindicated; 9. Accompanied by poor preoperative blood glucose control of diabetes (fasting blood glucose control not within the range of 3.9-13.8 mmol/L (68-250 mg/dL)) 10. Pregnant women; 11. Preoperative coagulation dysfunction; 12. Refusing to sign the informed consent form; 13. Those who cannot be selected for any reason in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total consumption of opioid drugs for patient-controlled analgesia in 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total consumption of opioid drugs for patient-controlled analgesia at 24 hours and 72 hours after surgery;The time from the end of the surgery to the first use of the pain relief pump for emergency pain relief;The incidence of nausea 24 hours and 48 hours after the operation;The incidence of vomiting 24 hours and 48 hours after the operation;The Recovery-15 scores at the time points of before the operation, 24 hours after the operation and 48 hours after the operation;The Numerical Rating Scale scores at 24 hours, 48 hours, and 72 hours after the operation; | — |
Countries
China
Contacts
Public ContactLiang Chao
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed