treatment resistant late life depression
Conditions
Interventions
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age>=60 years old; 2. Meet the diagnostic criteria for depressive disorders in the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5); 3. The total score of HAMD-17 >=17 points; 4. Sufficient doses of antidepressants with two different mechanisms in the past were ineffective. Patients had good medication adherence at the minimum or maximum tolerated dose, and the duration of each drug was not less than 4 weeks [42]. 5. Primary school education level or above, able to cooperate with the completion of the assessment and inspection; 6. Obtain written informed consent from the person or his family.
Exclusion criteria
Exclusion criteria: 1. Previous history of head disease, brain injury, seizures and other neurological diseases; 2. Have serious or unstable cardiovascular, respiratory, immune or other system diseases; 3. Past or current DSM-5 diagnosis of the following mental illnesses: organic mental disorder, Alzheimer's disease, secondary dementia caused by other causes, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder, undefined mental illness, alcohol (or drug) dependence or abuse, personality disorder; 4. Contraindications to MRI or transcranial magnetic therapy: such as electronic or metal implants (dentures, arterial clips, pacemakers or metal fixtures, etc.), claustrophobia, etc.; 5. Participated in interventional clinical trials in the previous 3 months before screening; 6. Pregnant, lactating women or those planning to become pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg depression rating scale,MADRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| 17-item Hamilton depression scale,HAMD-17;Hamilton anxiety rating scale,HAMA;Pittsburgh sleep quality index,PSQI;the geriatric depression scale,GDS;repeatable battery for the assessment of neuropsychological status,RBANS;Montreal cognitive assessment,MoCA;brain MRI; | — |
Countries
China
Contacts
Public ContactQinge Zhang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed