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A Study on the Neuroinflammatory, Oxidative Stress, and Gut Microbiota Biomarkers Related to the Therapeutic Efficacy of Gastrodin in Autism Spectrum Disorder Based on Metabolomics and Microbiomics

A Study on the Neuroinflammatory, Oxidative Stress, and Gut Microbiota Biomarkers Related to the Therapeutic Efficacy of Gastrodin in Autism Spectrum Disorder Based on Metabolomics and Microbiomics

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108243
Enrollment
Unknown
Registered
2025-08-27
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder

Interventions

Behavioral intervention
Gastrodin Intervention Group:Oral gastrodin

Sponsors

Kunming Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 8 Years

Inclusion criteria

Inclusion criteria: 1 Aged 3-8 years; 2 Those who meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) and have basically complete important relevant information in clinical data; 3 Those with a score of >= 53 on the Autism Behavior Checklist (ABC); 4 Children who can cooperate with doctors in treatment; 5 The parents of the patients are informed of the content of this study, voluntarily participate, and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1 Suffering from other severe mental illnesses; 2 Having a history of metabolic diseases, organic brain diseases, or other severe physical illnesses; 3 Children with severe aphasia, physical disabilities, or any other factors that may hinder the completion of neuropsychological assessments, or those who refuse to cooperate; 4 Having taken gastrodin supplements in the past 2 months; 5 Having used antibiotics or probiotics in the past 4 weeks 6 Failing to cooperate with treatment as required, etc.

Design outcomes

Primary

MeasureTime frame
autistic behaviors;

Secondary

MeasureTime frame
Oxidative Stress Indicators;Neuroinflammatory markers;Microbiomics Indicators;Metabolomics Indicators;

Countries

China

Contacts

Public ContactHuang Haoyu

Kunming Children's Hospital

345145728@qq.com+86 177 8700 9338

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026