Breast tumor
Conditions
Interventions
Gold Standard:Final Diagnostic Basis:
Comprehensive pathological evaluation of the surgically resected specimen, including:
Histological type: Classified according to the WHO classification of breast
Index test:Allelic expression status of the imprinted genes GNAS, GRB10, and SNRPN.
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: This study prospectively enrolls patients who have not undergone surgery, meeting the following criteria: 1. Age >= 18 years, regardless of gender; 2. Meeting the indications for biopsy as per the Breast Imaging Reporting and Data System (BI-RADS) outlined in the 2013 ACR guidelines; 3. No prior history of radical breast surgery, radiotherapy, neoadjuvant chemotherapy, or targeted therapy; 4. Non-pregnant and non-lactating patients; 5. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. RNA degradation in patient CNB or FNA samples, or tumor purity below the minimum detection threshold of the QCIGISH technology. 2. Incomplete clinical information (Note: Patients without immediate surgical indications or those who did not undergo surgery may be followed up).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specifity;Accuracy; | — |
Countries
China
Contacts
Public ContactYifeng Zhang
Shanghai General Hospital
Outcome results
None listed