Perennial Allergic Conjunctivitis
Conditions
Interventions
Allergic conjunctivitis group (All patients were managed by the same ophthalmologist, with identical treatment protocols maintained throughout the follow-up period.):None
Control group:No intervention
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
8 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1) Age: 8–12 years. 2) Clinical diagnosis of perennial allergic conjunctivitis (PAC): Diagnostic features included subjective symptoms (ocular itching, tearing, redness, and discharge occurring in multiple seasons or almost throughout the year) and objective signs (conjunctival hyperemia and chemosis without papillary hypertrophy). 3) Skin prick test (SPT): Positive for dust mite allergens. 4) Normal control group: Age- and sex-matched children without a history of allergic diseases or dry eye, and negative for dust mite allergens on SPT. 5) Refractive status in both groups: Spherical equivalent refractive error between -3.00 D and +3.00 D.
Exclusion criteria
Exclusion criteria: 1) Ocular diseases: Exclusion of other ocular diseases, including history of ocular surgery or trauma, entropion with trichiasis, eyelid malformations, active ocular infections, and a history of topical or systemic medications within the past 3 months. 2) Systemic diseases: Poor general condition, inability to cooperate with ocular examinations, or presence of systemic diseases such as rheumatoid arthritis, systemic lupus erythematosus, Stevens-Johnson syndrome, nephrotic syndrome, and other systemic immune disorders. 3) Refractive status: Children in either group with a spherical equivalent refractive error less than -3.00 D or greater than +3.00 D.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal biomechanics;Tear inflammatory cytokines; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ocular itching score;Conjunctival hyperemia score;OSDI score; VAS score;Tear river height;Tear film breakup time;Corneal fluorescence staining score; | — |
Countries
China
Contacts
Public ContactJing Wang
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed