Neonatal hypoxic ischemic encephalopathy
Conditions
Interventions
Experimental group:None
Control group:None
Sponsors
Ningbo Mingzhou Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The cases in the experimental group met the diagnostic criteria for neonatal HIE and the degree of HIE brain injury. The cases in the control group simultaneously met all the following conditions: 1 the mother was healthy; 2 the fetal heart rate and fetal movement during pregnancy were normal; 3 the newborn was healthy within one week after birth; 4 congenital malformations and other diseases were excluded. The gestational age was 37 to 42 weeks, and the weight was 2500 to 4000 grams. The cases in the experimental group met the diagnostic criteria for neonatal HIE and the degree of HIE brain injury. The diagnosis of HIE and the degree of brain injury was based on the clinical manifestations of the newborn: HIE Diagnosis 1 There was a clear abnormal obstetric history that could cause fetal distress in utero; and there were severe signs of fetal distress in utero or a clear history of asphyxia during delivery; 2 Severe asphyxia at birth, defined as an Apgar score of =3 at 1 minute and =5 at 5 minutes, and/or umbilical artery blood gas with pH =7.00 at birth; 3 Neurological symptoms appeared shortly after birth and persisted for more than 24 hours, such as changes in consciousness, changes in muscle tone, abnormal primitive reflexes, and in severe cases, convulsions, brainstem symptoms, and increased tension in the anterior fontanelle; 4 Exclude convulsions caused by electrolyte imbalances and birth injuries, as well as brain injuries caused by genetic metabolic diseases, intrauterine infections, and other congenital diseases. All four conditions must be met for a confirmed diagnosis. If the fourth condition cannot be determined temporarily, it can be considered a suspected case. Degree of HIE Brain Injury Mild: Excitement, easily irritated; normal muscle tone and sucking reflex, active Moro reflex, no convulsions, stable breathing. Moderate: Drowsiness or inhibition, weakened Moro and sucking reflexes, decreased muscle tone. Convulsions may occur. Severe: Coma, disappearance of tendon reflexes and Moro reflex, extremely low and flaccid muscle tone. Unequal pupils; poor light response. Anterior fontanelle bulging, frequent convulsions, apnea or irregular breathing, and even respiratory failure. HIE was diagnosed by ultrasound: Head ultrasound was performed 3 to 7 days after birth. One of the following changes indicated HIE: 1 Symmetrical focal hyperechoic areas around the ventricles within one week after birth; 2 Hyperechoic areas forming low-echo cystic softening foci within 1 to 3 weeks after birth; 3 Disappearance of cystic softening foci within 1 to 2 months, with severe cases showing obvious ventricular dilation. The degree of HIE brain injury was classified according to the LA Papile grading method. The inclusion criteria for the control group cases were: simultaneously meeting all the following conditions: 1 the mother was healthy; 2 normal fetal heart rate and fetal movement during pregnancy; 3 healthy within one week after birth; 4 excluding congenital malformations and other diseases. The gestational age was 37 to 42 weeks, and the weight was 2500 to 4000 grams.
Exclusion criteria
Exclusion criteria: There are intrauterine infections and congenital genetic metabolic diseases, congenital malformations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabonomics;proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Umbilical cord blood pH value;Degree of neonatal asphyxia;Clinical manifestation assessment;Imaging assessment; | — |
Countries
China
Contacts
Public ContactYanxia Zhao
Ningbo Mingzhou Hospita; Ningbo College of Health Sciences
Outcome results
None listed