Frailty
Conditions
Interventions
Nutrition and Exercise Synergistic Intervention Group:The nutritional and exercise combined intervention group, on the basis of the routine postoperative guidance, was given oral nutritional supplemen
at the same time, 3g of whey protein powder with ß-hydroxy-ß-methylbutyric acid calcium (Ca-HMB) was given daily, taken orally in 2 divided doses with the nutrients. In terms of exercise intervention,
Conventional postoperative guidance group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 60 years and no more than 85 years; 2.Postoperative discharge patients who underwent elective major abdominal surgeries (grade 3/4) during hospitalization.
Exclusion criteria
Exclusion criteria: 1. Severe intestinal flora imbalance; 2. Patients who are unable to take oral nutritional supplements; 3. Patients unable to participate in exercise rehabilitation training; 4. Patients with severe infection requiring long-term anti-infective treatment; 5. Receiving probiotics during perioperative period; 6. History of severe oral diseases and oral inflammation (evaluation criteria: 1) Clinical diagnostic criteria: active periodontitis (depth of periodontal pocket >=5mm, bleeding on probing); Oral ulcer size >=1cm² or lasting > 2 weeks; Acute suppurative mumps or maxillofacial cellulitis; Severe caries, that is, dental pulp involvement may require root canal treatment. 2) Auxiliary examination: confirmed by clinical examination and imaging (such as panoramic X-ray) by dentists; 7. The presence of severe heart, lung, liver, and kidney dysfunction (evaluation criteria strictly follow the international authoritative guidelines to define severe organ dysfunction: 8. NYHA III-IV or ACC/AHA Stage C-D; 9. Lung function was assessed according to GOLD grade 3-4. 10. Child-Pugh C or more than twice the normal liver function; 11. Renal function based on KDIGO G4-G5 to ensure the safety of the study population and data reliability); 12. Inability to complete follow-up or data collection; 13. Other reasons for investigator ineligibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative improvement rate of frailty state; | — |
Countries
China
Contacts
Public ContactMingwei Zhu
Beijing Hospital/National Center for Geriatrics
Outcome results
None listed