Catheter-Related Bladder Discomfort
Conditions
Interventions
Esketamine Treatment Group:For patients with moderate CRBD, the treatment dose was determined using the Dixon up-and-down sequential allocation method with a step size of 0.025 mg/kg. The first patien
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 65 years; 2. American Society of Anesthesiologists (ASA) Physical Status Class I or II; 3. Postoperative indwelling urinary catheter following urological surgery; 4. Diagnosis of moderate Catheter-Related Bladder Discomfort (CRBD) after extubation (removal of endotracheal tube) or removal of the laryngeal mask airway; 5. Recovery in the Post-Anesthesia Care Unit (PACU).
Exclusion criteria
Exclusion criteria: 1. Chronic pain or history of opioid abuse; 2. Bladder outflow obstruction; 3. Urinary tract infection; 4. Heart failure (ejection fraction 180/100 mmHg); 6. Cardiac arrhythmias (e.g., sinus bradycardia, heart block, atrial fibrillation); 7. Elevated intracranial pressure and central nervous system injury or disease; 8. History of or current severe psychiatric disorder; 9. Elevated intraocular pressure (e.g., glaucoma) or penetrating eye injury; 10. Untreated or inadequately controlled hyperthyroidism; 11. Liver cirrhosis; 12. Chronic kidney disease; 13. Overactive bladder (nocturia >3 times/night or urinary frequency >8 times/24 hours); 14. Morbid obesity (Body Mass Index, BMI > 40); 15. Known hypersensitivity to the active substance (esketamine) or any excipient of the drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| median effective dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90% effective dose;Esketamine-Associated Adverse Effects; | — |
Countries
China
Contacts
Public ContactZhaoli Wang
Peking University Shenzhen Hospital
Outcome results
None listed