treatment resistant late-life depression
Conditions
Sponsors
Capital Medical University Affiliated Beijing Anding Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Initial onset age of 60 years or older; 2. Meeting the diagnostic criteria for depressive disorders as outlined in the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5); 3. A total score of 17 or higher on the Hamilton Depression Rating Scale-17 (HAMD-17); 4. Inadequate response to two or more antidepressants with different mechanisms of action, administered at adequate doses and durations (dose should be at least three times the minimum effective dose or two-thirds of the maximum effective dose; duration should be a minimum of three months of full treatment after reaching the threshold dose), with a reduction rate of HAMD less than 50%; 5. Educational attainment of at least primary school level, capable of cooperating to complete assessment examinations; 6. A score of less than 26 on the Montreal Cognitive Assessment (MOCA); 7. Written informed consent obtained from the individual or their family.
Exclusion criteria
Exclusion criteria: 1. History of cranial diseases, brain injury, epileptic seizures, or other neurological disorders; 2. Presence of severe or unstable cardiovascular, respiratory, immune, or other systemic diseases; 3. Previous or current diagnosis of the following psychiatric conditions according to DSM-5: organic mental disorders, Alzheimer's disease, secondary dementia due to other causes, schizophrenia, schizoaffective disorder, bipolar affective disorder, delusional disorder, unspecified mental illness, alcohol (or drug) dependence or abuse, personality disorders; 4. Contraindications for magnetic resonance imaging or transcranial magnetic therapy, such as the presence of electronic or metal implants (dentures, arterial clips, pacemakers, or metal fixations), claustrophobia, etc.; 5. Participation in an interventional clinical trial within the three months prior to screening; 6. Pregnant, lactating women, or those planning to become pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive symptom ; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function; | — |
Countries
China
Contacts
Public ContactRen Li
Capital Medical University Affiliated Beijing Anding Hospital
Outcome results
None listed