Muscle-bone-brain degenerative diseases
Conditions
Interventions
Observation group:none
Sponsors
The Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clear disease diagnosis: one of the following diseases that meet international or domestic diagnostic criteria: sarcopenia (AWGS 2019 standard); Osteoporosis (DXA bone density T-value <=-2.5 or history of fragility fracture); Ankylosing spondylitis (ASAS classification criteria); ossification of the ligamentum flavum (OLF) or herniated disc (confirmed by MRI/CT); Alzheimer's disease (AD) (NIA-AA diagnostic criteria); 2. Age range: greater than or equal to 18 years old; 3. Informed consent: voluntarily sign the informed consent form and cooperate with follow-up and sample collection.
Exclusion criteria
Exclusion criteria: 1. Severe comorbidities: Malignant tumors (active tumors within 5 years, excluding non-melanoma skin cancer); End-stage organ failure (such as NYHA class IV cardiac function, eGFR < 30 mL/min); Uncontrolled infections or immunodeficiency diseases (such as HIV/AIDS); 2. Those with drug, alcohol or substance dependence; 3. Those with severe mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basic Information;Smoking history;Alcohol consumption history;Previous medical history;Muscle homeostasis;Bone metabolism assessment;Spinal degeneration condition;Cognitive function;Imaging indicators;Mental state;Weakness Questionnaire; | — |
Countries
China
Contacts
Public ContactXiaobing Jiang
The Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed