Postoperative delirium
Conditions
Interventions
Helicobacter pylori positive group:Perform carbon-13 breath test before surgery
Helicobacter pylori negative group:Perform carbon-13 breath test before surgery
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) American Society of Anesthesiologists (ASA) classification II-III 2) Obtain informed consent form; 3) Age over 65 years old; 4) Patients planning to undergo surgery for gastrointestinal tumors;
Exclusion criteria
Exclusion criteria: 1) Severe heart, lung, liver and kidney dysfunction; 2) History of mental illness or long-term use of psychotropic drugs (dementia, schizophrenia), chronic analgesic medication, and alcohol abuse; 3) Patients with preoperative CAM positivity 4) Patients diagnosed with severe cognitive impairment have >= 8 errors in the preoperative Simplified Mental State Questionnaire (SPMSQ); 5) Have experienced any cerebrovascular accidents within the past 3 months, such as stroke, transient ischemic attack (TIA), etc; 6) Patients with diabetes who have serious complications (diabetes ketoacidosis, hypertonic coma, various infections, macroangiopathy, diabetes nephropathy); 7) Patients with severe infections; 8) Preoperative PaO2<60mmHg or SpO2<92%; 9) Participated in another drug clinical study within the past 30 days; 10) Language communication barrier, unable to complete cognitive function tests; 11) Use of antibiotics in the past three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU transfer rate;Tracheal intubation extraction time;Postoperative hospitalization days;Postoperative complications (cardiovascular, pulmonary, etc.);30 day postoperative mortality rate;Postoperative pain score;Serum inflammatory factor levels in perioperative patients; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed