Colorectal neoplasm surgery
Conditions
Interventions
Disodium phosphonoformate group:Use of sodium propofol for induction and maintenance of anesthesia
Propofol group:Induction and maintenance with propofol
Sponsors
The Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Obtain informed consent from participants and their families and have them sign the clinical trial informed consent form. (2) Age 65–85 years, American Society of Anesthesiologists (ASA) physical status classification I–III, body mass index (BMI) 18–30 kg/m². (3) Preoperative pathology report confirming colorectal cancer, with planned laparoscopic radical resection of colorectal cancer.
Exclusion criteria
Exclusion criteria: (1) Patients with preoperative comorbid mental disorders, such as Alzheimer's disease; (2) Patients with preoperative cognitive impairment; (3) Patients with severe organ dysfunction prior to surgery; (4) Patients with a BMI less than 18 kg/m^2 or greater than 30 kg/m^2; (5) Allergy to propofol or propofol components; (6) Failure to remove the tube promptly postoperatively, resulting in admission to the ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia induction success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters;The unit time dosage of propofol sodium, propofol, and remifentanil during anesthesia maintenance, as well as the use of related drugs during surgery (atropine, methoxamine, norepinephrine, and dopamine);Quality of awakening;Incidence of adverse events within 72 hours after surgery; | — |
Countries
China
Contacts
Public ContactYang Yujiao
The Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed