Chronic obstructive pulmonary disease
Conditions
Interventions
Experimental group:Routine treatment combining with bronchoscopy, bronchoscopic airway clearance therapy and bronchoalveolar lavage
Control group:Routine treatment combining with bronchoscopy
Sponsors
Meizhou People’s Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Both men and women, age >=40 years old; 2. FEV1/FVC less than 0.7 after inhalation of bronchodilators; 3. Definition of acute exacerbation period: worsening dyspnea, increased sputum volume, or purulent sputum within 2 weeks, with two or three of the above symptoms; 4. Signed informed consent before participating in the study.
Exclusion criteria
Exclusion criteria: 1. Contraindications of bronchoscopy: myocardial infarction within 1 month; active massive hemoptysis; coagulation dysfunction; pregnancy; malignant arrhythmia, severe cardiac insufficiency, systemic failure, etc.; 2. Patients with known respiratory diseases other than COPD, including active tuberculosis, sarcoidosis, lung cancer, pulmonary fibrosis, cystic fibrosis, or diseases that could significantly affect clinical evaluation according to the judgment of investigators; 3. Presence of nervous system diseases affecting the ability to expectorate, including Stroke or Parkinson's disease, etc.; 4. Unable to read or understand Mandarin, or unable to understand and complete questionnaires in the study; 5.Conditions where investigators assessed the patient as ineligible for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| COPD Assessment Test (CAT); | — |
Secondary
| Measure | Time frame |
|---|---|
| modified Medical Research Council dyspnea scale (mMRC);EXAcerbation of Chronic pulmonary disease Tool (EXACT); | — |
Countries
China
Contacts
Public ContactCheng Yang
Meizhou People’s Hospital
Outcome results
None listed