Adolescent depression
Conditions
Interventions
active stimulation group:A high-current, variable-frequency transcranial alternating current stimulation (tACS) protocol was applied with individualized parameter adjustment. The stimulation parameter
sham stimulation group:By briefly ramping the current up and down to mimic real stimulation, the sham stimulation group had the same electrode placement as the active stimulation group but received no
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
12 Years to 24 Years
Inclusion criteria
Inclusion criteria: 1. Core Disease Characteristics: Meet the DSM-5 diagnostic criteria for Major Depressive Disorder (MDD) without psychotic features, presenting with at least 4 additional symptoms (e.g., retarded thinking, sleep disturbances, excessive/low self-evaluation, etc.), and independently confirmed by two psychiatrists; 2. Severity: Baseline score on the 24-item Hamilton Depression Rating Scale (HAM-D-24) >= 18 points or Montgomery-Åsberg Depression Rating Scale (MADRS) score >= 22 points, ruling out mild cases and those with significant psychotic features; 3. Demographics: Age 12-24 years, any gender, with informed consent signed by a legal guardian; 4. Treatment History: No current use of antidepressant medication or medication maintained at a stable dose for >= 4 weeks (i.e., adequately washed out or stabilized).
Exclusion criteria
Exclusion criteria: 1. Patients with schizoaffective disorder, dysthymia, or bipolar depression; patients with any anxiety disorder as the primary diagnosis within the past year; obsessive-compulsive disorder; substance abuse or dependence; personality disorders; 2. Presence of intracranial metal implants or any other condition deemed unsuitable for this treatment; 3. Patients with severe or unstable diseases of the heart, liver, kidney, endocrine organs, blood, or autoimmune system; patients with epilepsy or other organic brain diseases; patients with increased intracranial pressure, refractory hypertension, or glaucoma; 4. History of severe suicide attempts, current high suicide risk, or a score >=3 on item 3 (suicide) of the HAMD; 5. Prior use of ketamine or other NMDA receptor antagonists; 6. Receipt of systematic antipsychotic drug treatment within 2 weeks before enrollment; 7. Receipt of electroconvulsive therapy, rTMS, or systematic psychotherapy within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-24 items (HAMD-24); | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery–Asberg depression rating scale (MADRS);Columbia Suicide Severity Rating Scale (C-SSRS);Perceived Deficits Questionnaire–Depression (PDQ-D);Digit Symbol Substitution Test (DSST);Quality of Life (QoL);Sheehan Disability Scale (SDS); | — |
Countries
China
Contacts
Public ContactPing Guo
Children’s Hospital of Soochow University
Outcome results
None listed